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A new weighted scheme is suggested for forecast of magnetic activity 3 h in advance by accumulation of selected magnetic indices ranked by decreasing order for 12 hrs preceding given time of observation.
On day 14, both CR and RF mice again showed significantly more activity during the several hrs preceding food delivery (p<0.05, Kruskal Wallis Test with Dunn's post test) (Fig. 1E).
When the total seconds of high activity in the 3 hrs preceding feeding is normalized by dividing by the total number of seconds in the entire 24 hr recording period, both CR and RF mice had a significantly greater fraction of activity than mice on AL diets on days 0, 7, 14, 21, and 28 (Fig. 1H).
When the total number of seconds of high activity is summed over the 3 hrs preceding feeding (ZT 4 6), mice on both CR and RF diets had significantly more high activity than the mice on AL diets from day 0 onwards (Fig. 1G).
The lack of significant increase in FAA in NPY KO mice until day 14 could be interpreted as a delayed onset of FAA in NPY KO mice since FAA is significantly increased in NPY WT mice on CR from day 7 though it is clear that there is a strong trend toward increased activity in the three hrs preceding feeding at day 7 in the NPY KO mice on CR.
Nonetheless, we plan to evaluate personal PM exposure levels for the 24 hrs preceding controlled exposures in future studies in order to directly assess this issue.
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(C ) Fraction of high activity in the 3 hr preceding expected meal time.
(G ) Amount of high activity in the 3 hr preceding scheduled feeding in seconds.
In Amsterdam and Helsinki, indoor and personal PM2.5 were measured during the 24 hr preceding the clinic visit.
(H ) The sum of normalized high activity in the 3 hr preceding scheduled injection at each behavioral measurement.
We found greatest effect modification for FGB rs1800790 for increased CO during the 6 11 hr preceding sampling.
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