Information regarding the potential extrapulmonary adverse effects of albuterol within the 4 h of DEM presentation, including heart rate (HR), corrected QT (QTc) interval, serum potassium level and blood sugar level (BSL), was collected from hospital medical records.
No statistically significant underestimation was found when maximal HR was corrected according to the Tanaka (208 0.7 · age) or Nes (211 0.64 · age) formulas, or for values expressed in l/min or for values expressed in ml · kg−1 · min−1.
In ovarian cancer patients, overexpression of HER2/neu correlated closely with overall survival (univariate hazard ratio (HR) 2.59, P=0.005; multiple corrected HR 1.92, P=0.074).
The corrected HRs estimates show a clear difference in HRs between the first tertile and the other two, in particular after about 108 months with a steep increase in the HR.
QT intervals were then also corrected for HRs using the following formula: QTc = QT/ RR/100 1/2, where QTc is the corrected QT interval and RR is the R-R interval (26).
The pre-exercise values of PEP, LVET and ratio PEP/LVET were corrected for HR according to Weissler's formulas (1972): PEPI = (0.4 × HR) + PEP, LVETI = (1.7 × HR) + LVET, PEP/LVETIndex = (0.0168 × HR) + PEP/LVET.
HRs were calculated as the average HRs of the five datasets, corrected for between- and within-imputation variation [ 26- 28].
The QT interval is often corrected for HR, defined as corrected QT (QTc).
On Cox's proportional-hazard model regression (Table 3), there was a strong effect of AAff, which was associated with a greater metastatic rate than AAFF/Ff (HR 4.7, P=0.03) when corrected for the other covariates.
Differently to conventional gene therapy approaches, HR ensures that the corrected gene will be expressed in an appropriate temporal and tissue-specific manner under the regulation of endogenous cis-elements.
