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One exception was a HR tumour with MNA and 1pLOH that progressed during HR treatment and the patient eventually died.
Surprisingly, we found that Gli2P1-4 is localized to the tips of cilia in the presence of DMSO (Fig. 4C, Table 2; n = 30/30 for 4 hr treatment and 30/33 for 18 hr treatment), but not in the presence of forskolin (Fig. 4C, Table 2; n = 1/31 for 4 hr treatment and 11/68 for 18 hr treatment).
Interestingly, we found that forskolin treatment greatly diminishes the ciliary localization of Gli2 (Fig. 4A, Table 2, n = 0/60 for 4 hr treatment and 10/95 for 18 hr treatment), but only moderately reduces the ciliary localization of Gli1 (Fig. 4A, Table 2, n = 14/30 for 4 hr treatment and 26/43 for 18 hr treatment).
After 24 hr treatment with peptides, a profound increase in α7-nAChR protein levels was observed.
Similar results were obtained when sulindac was included during the 2 hr treatment with the oxidizing agent.
The Gadd45b gene was reported to be induced by a 24 hr treatment with TCPOBOP in the mouse liver [21].
Similar(13)
The model predicted that following the 4-hr treatment, inflammatory mediators would have distinctive temporal and quantitative expression patterns across treatment assignments.
Lung secretagogues were added following a 1-hr treatment of the cells with Baf A1, since by this time the pH gradient was lost.
For this purpose, co-immunoprecipitation of two differentially tagged ABCG2 was performed as previously described [2] following a 6-hr treatment with PZ-39 at 3.3 µM.
The anti-inflammatory mediator IL-10 was predicted to be secreted rapidly after the 4-hr treatment and remain elevated up to Day 3 post-injury.
Next, we measured protein degradation and synthesis rates after a 20-hr treatment with bortezomib.
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