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However, physostigmine at the dose we used did not affect HR, indicating that HR reduction does not play a major role in the attenuation of blood flow recovery.
Some HR-lowering agents have been shown to improve clinical outcomes, although whether HR reduction is the only mechanism of benefit is hard to demonstrate and could be reductive.
Similar HR reduction obtained with both drugs implies that the effect of ivabradine treatment goes beyond the HR.
We revealed Amiodarone-mediated QTc prolongation, HR reduction and HRV increase otherwise masked by sedation.
HR reduction tended to be lower in animals fed after weaning with OB diet (P = 0.07) (Figure 3C D).
Similar(21)
However, the authors demonstrate that β-blocker-induced HR reductions do not increase adverse outcomes in severe sepsis.
At 1 minute, the absolute reduction in HR was lower in the HC group (25.7 ± 8.4 vs 35.3 ± 11.0 beats/min, p <0.001).
Moreover, our data suggest that inhibiting the IGF-1R pathway suppresses HR by reduction in expression of RAD51.
After 48 hr, significant reduction in IC50 values of C-HNC-G and M-HNC-G was observed (in IC50 values of 12.08 ± 0.24 μM and 1.57 ± 0.03 μM, respectively.
We noted that the effects of PM2.5 on increases in average HR and reduction of HRV depended on individual's obesity status, with more aggravated electrophysiologic responses observed in obese subjects.
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