Over the last twelve months, more than 500 companies have adopted Zenefits HR management tools, meaning that the company now manages payroll, benefits and HR (or some combination thereof) for over 5,000 employees.
In the analyses, the above mentioned prognostic factors are assumed to represent a constant hazard ratio (HR) over time, meaning that a prognostic factor has the same influence on claim duration throughout the claim period.
Consequently, similar to other biomarkers such as estrogen receptor testing as a companion diagnostic for hormonal therapy, genomic scars are likely to prove to be high-negative predictive value (NPV) biomarkers of response to HR deficiency-targeting drugs, meaning that the great majority of patients who test negative for the biomarker will not benefit from the therapy.
Moroever, similar negative findings emerged when looking at initial HR deceleration, subsequent HR acceleration, and variability in HR response during the offer period, meaning this pattern of findings is not an artefact of the particular analysis strategy we adopted.
Although rats with unilateral MFC lesions in both experiments showed a deficit in effort-based decision-making (Block B), they nevertheless all returned to choosing the HR option when an equivalent barrier was placed in both the HR and LR goal arms, meaning that they had to expend the same amount of effort to gain either reward size (Block C).
A Cox PH model assumes the hazard ratio (HR) is constant over time, meaning the association of a covariate is the same at all time points.
In practice, nearly all participants underestimated their HRs in the present sample, meaning that the modulus and nonmodulus scores were extremely similar (r =.98, p <.001).
In the 'neither' case, the ME became significantly negative, meaning that the uncertainty in the reconstructed HRs was underestimated.
