Exact(22)
In contrast, the control mice showed significant spatial bias for the target quadrant during the first (Fig. 4I) and second 24 hr delay probe trials (p<0.0006), but not for either of the 1 hr delay probes.
Of the animals injected in posterior sensorimotor cortex, ZIP was injected with a 24 hr delay after the last training episode for two rats, and with a 4 hr delay for three rats; the results were indistinguishable and therefore combined.
The LD cycle was phase advanced by 6 hr, followed by a 6 hr delay after a week.
Probe trials on days 5 and 10 of place training were also different in that mice received a 30 s probe before testing on day 5 or 10 (24 hr delay) and a 30 s probe after place training on those days (1 hr delay).
Simultaneous administration of 5 µg P-2 siRNA and 100 or 10LD50 virus resulted in 48 and 96 hr delay respectively in the appearance of symptoms and death (Fig 7a and b).
However, although no differences between groups were found for platform crossings in the 1 hr delay probe trial on day 5, the control mice exhibited a significant spatial bias for the target quadrant, (p<0.007 for target vs each of the other quadrants), while the PCP-treated group did not (Fig. 4F).
Similar(37)
We then assayed the ability of rats with binocular induced glaucoma to entrain their daily locomotor activity to successive 6 hr delays of LD cycles each coupled with 1 log unit decreases in light levels (100, 10 and 1 lux).
Probe trial performance midway through acquisition training (day 5) indicated no significant differences between the groups in terms of platform crossings or spatial bias for the target quadrant during the 24 hr delayed probe.
Specifically, the PCP-treated mice made significantly fewer platform crossings during the first, 24 hr delayed probe trial (p = 0.047) relative to the controls and they never showed significant spatial bias for the target quadrant during any of the four probe trials.
The ROC analysis showed similar areas under curves (AUC) of S3 h/1 h (AUC = 0.968), S3 h/2 h (AUC = 0.913), but better than S2 h/1 h (AUC = 0.795), suggesting the relative importance of the 3 hr delayed scan data.
Furthermore, in accordance with complete downregulation of TRAILR expression by 48 hr, delaying the addition of neutrophils or soluble TRAIL to MCMV-infected fibroblasts until this time point abrogated antiviral activity.
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