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The mouse pale ear mutant, HPS1 ep, is the model for the most common HPS disease, HPS 1, while the pearl mutant, Ap3b1 pe, is the model for HPS 2. As for all HPS genes, the products HPS1 and HPS2 (a subunit of the AP-3 adaptor complex, Feng et al. 1999), respectively, are involved in vesicle trafficking and the secretory process, and known to influence separate pathways (Feng et al. 2002).
Old World hantaviruses are associated with hemorrhagic fever with renal syndrome (HFRS), whereas New World hantaviruses cause hantavirus pulmonary syndrome (HPS) (1 ).
Since the identification in 1993 of SNV as the cause of HPS (1 ), numerous cases of this disease have been confirmed in various regions of North and South America.
Hantaviruses (family Bunyaviridae, genus Hantavirus) are rodentborne or insectivoreborne viruses; some are recognized causes of human hemorrhagic fever with renal syndrome or hantavirus pulmonary (or cardiopulmonary) syndrome (HPS) (1 ).
Members of the genus Hantavirus (family Bunyaviridae) are commonly transmitted to humans through rodents and may cause 2 severe human diseases: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome (HPS) (1 ).
In the Americas, hantavirus species that occur at low frequency are associated with the severe disease hantavirus pulmonary syndrome (HPS) (1, 2 ), and species that occur at higher frequency are associated with milder disease (3 – 5 ).
Similar(53)
To compare clinically 2 different subtypes of Hermansky Pudlak syndrome (HPS), type 1 (HPS-1) and type 3 (HPS-3).
As expected, NK progenitors were more enriched in CD45+ ES-HPs (1 in 53 or 1.9%) than in CD45− ES-HPs (1 in 286) (Fig. 2C) (Table 1).
In European Americans (EA) they have been reported as 16% HP 1 1, 48% HP 1 2, and 36% HP 2 2[ 5].
The genotype frequencies were 13.9% HP 1– 1, 41.8% HP 1– 2, and 44.3% HP 2 2 and were consistent with Hardy-Weinberg proportions.
The protein products of the Hp 1 and Hp 2 alleles are structurally and functionally distinct.
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