Surprisingly, binding sites of several members of the forkhead family of transcription factors, that are however not well characterised were also significantly found to be overrepresented in our dataset.
The precise relationship between water and the persistence and spread of F. tularensis is, however, not well characterised, much due to the fact that the bacterium is difficult to culture from water samples (6, 7).
However, while often well characterised quasi-statically, there is typically a paucity of information on the high strain-rate response of such materials in the literature.
However, there are well characterised pathogenic strains of diarrheagenic E. coli (DEC) and extra-intestinal pathogenic E. coli (ExPEC) such as uropathogenic E. coli (UPEC) that infect tissues other than the endometrium [13] [15].
The extent to which these aggregates represent biologically meaningful structures remains unclear; however there are well characterised examples in which the assembly of higher-order structures regulates flux through specific metabolic pathways.
However, besides the well characterised effects of HIF-1 α on angiogenesis and vessel maturation, a molecular mechanism for the proposed inhibitory action of blocking HIF-1 α on gastric cancer is lacking and the precise relevance of HIF-1 α for the causal pathogenesis of gastric cancer is not well defined.
The enamel pellicle formation is well characterised, however the mucosal pellicle proteins have only recently been clarified and what drives their formation is still unclear.
The phenotypic effects of some CNVs are well characterised, however, it remains unclear how much information reaches the parents of affected children and by what route.
The role for S100A9 in the malignant cells is not well characterised; however, previous studies have shown that the protein could have important immune-modulating properties.
Established animal models of prostate and bladder development are well characterised; however, despite providing key insights for differentiation, there are limitations in translating these findings to the human setting.
However, by focusing on well characterised effects in a defined trait, instead of general inbreeding depression in fitness, we have shown that it is possible to identify major genetic factors and these will likely be amenable to detailed molecular characterisation.
