Although the THP-1 response can hint to potential responses that might occur ex vivo or in vivo, these should be, however, validated by in vivo studies to draw more definite conclusions.
Our results of cisplatin sensitization from NSCLC were however validated also in ovarian cancer cells which were sensitized to cisplatin upon siRNA knockdown of DKK1.
These DXA measures were, however, validated previously in piglets using biochemical assessment of carcass N content and lipid extraction to determine lean and fat mass, respectively.
It became apparent that 3D cultures are generally more resistant to chemo- and radiotherapy than their 2D counterparts [ 8, 9], however validated three-dimensional in vitro tumour cell models allowing for fast and standardized drug screening are not routinely employed.
The association was, however, not validated in independent replication cohorts, including a total of 3,467 subjects, even though homozygous carriers of the minor A-allele on average were ∼1 3 BMI units heavier than homozygous carriers of the G-allele [17].
The scale has however been validated in a number of Sub Saharan African countries.
Our observations should, however, be validated in another population outside of Mayo Clinic.
The models, however, were validated in the SWS, where the pregnancies occurred more recently (8-16 yeago ago).
The Tegner score is an accepted activity score (Briggs et al. 2009); it is has not, however, been validated in Dutch.
This instrument has, however, been validated in the elderly general population, with a cutoff point of 16, which corresponds to clinically significant levels of depressive symptomatology and warrants clinical intervention (13).
