however most significantly

USAGE SUMMARY

The phrase "however most significantly" is not correct as it is missing a comma after "however." You can use it to introduce a contrasting point that emphasizes the importance of the following statement.
Example: "The project faced many challenges; however, most significantly, it brought the team closer together."

⚠ May contain grammatical issues

Science

News & Media

Human-verified examples from authoritative sources

Exact Expressions

2 human-written examples

However, most significantly, there is little evidence for large paralogous expansions within either individual taxa or supergroups, suggesting that the overall configuration of the KAP-β family has been retained during post-LECA evolution.

Plosone

Consistent with reported literature, we also observed PDGFC enriched in the epidermis and weakly in the dermis; however, most significantly, we observed PDGFC on the basement membrane (Fig. 1B).

DMM Disease Models and Mechanisms

Human-verified similar examples from authoritative sources

Similar Expressions

58 human-written examples

Iphigene Sulzberger's sensibility, however, was forged most significantly by watching her father remake The Times into a successful paper -- one in which the profit motive, while important, was secondary to a far larger journalistic purpose.

The New York Times

However, most did not significantly improve the inhibition of EGFR autophosphorylation or EGF dependent proliferation, and importantly, competition with peptide substrate or ATP was not examined.

ACS Chemical Biology

However, the pathway most significantly affected by the deletion of PPAR γ was the ribosome pathway (Additional file 6: Supplemental Figure S6), which controls genes involved in protein translation and synthesis.

BMC Gastroenterology

Most significantly, however, is the fact that going to a show is a social event.

The Guardian - Music

Perhaps most significantly, however, she jealously insisted on being the model for every single woman he painted.

The Guardian - Arts

Most significantly, however, would be the deterrent effect by decimating the market for abusive tax avoidance schemes by changing the risk-reward ratio.

The New York Times

Most significantly, however, the friendship, suggesting a hitherto unrealised closeness between the police and News International, is itself threatening the perceived probity of the Metropolitan police and its commissioner, Sir Paul Stephenson.

The Guardian

Most significantly, however, she has turned against Fran and now disputes the emotional evidence that Fran gave against her father in court, during which she said: "He wanted everybody to be his slave".

The Guardian

Most significantly, however we understand the meaning of her words in the unfortunate interview, they are utterly belied by her actions.

The New York Times

Expert writing Tips

Best practice

When using "however" to introduce a contrasting point, ensure it is followed by a comma before adding emphasis with "most significantly". The correct construction is: "However, most significantly,...". Ensure clarity and flow by placing the comma correctly.

Common error

A frequent error is omitting the comma after "however" when using it to introduce a contrast, creating awkward phrasing. Always insert a comma after "however" before continuing the sentence: "However, most significantly,..." is grammatically sound.

Linguistic Context

The phrase "however most significantly" functions as a conjunction phrase used to introduce a contrasting point while emphasizing its importance. However, it is grammatically incorrect without a comma after "however", as indicated by Ludwig AI.

Expression frequency: Rare

Frequent in

Science

50%

News & Media

50%

Formal & Business

0%

Less common in

Encyclopedias

0%

Wiki

0%

Social Media

0%

Ludwig's WRAP-UP

In summary, the phrase "however most significantly" is used to introduce a contrasting point while emphasizing its importance. However, it is deemed grammatically incorrect by Ludwig AI due to the missing comma after "however". The correct form is "However, most significantly,". While found in scientific and news contexts, its usage is rare, and alternative phrases like "however most importantly" are recommended for better clarity and grammatical correctness. Remember to punctuate correctly to maintain formality and ensure clear communication.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

however most importantly

Replaces "significantly" with "importantly" to convey greater emphasis on what follows.

however above all

Emphasizes a point as being more important than others previously mentioned.

but most importantly

Replaces "however" with "but" to offer a direct contrast and highlights the key point.

yet more crucially

Uses "yet" to indicate a contrast and "crucially" to highlight the significance.

nevertheless principally

Emphasizes the primary aspect despite what has been mentioned before.

nonetheless paramountly

Indicates that what follows is of utmost importance despite preceding statements.

even so chiefly

Highlights the main point despite any preceding information.

in spite of that primarily

Expresses that something is fundamental or essential despite what has been said.

regardless centrally

Indicates that the following point is key regardless of prior statements.

despite everything mainly

Despite any previous points, focuses on the main aspect.

FAQs

How should I properly punctuate a sentence that starts with "however" followed by an adverbial phrase?

When using "however" to introduce a contrasting element followed by an adverbial phrase like "most significantly", ensure you include a comma after "however". For example, use "However, most significantly,...".

What are some alternative phrases to "however most significantly" that I can use in my writing?

You can use alternatives such as "however most importantly", "but most importantly", or "however above all" to express contrast and emphasis.

Is it grammatically correct to say "however most significantly" without any punctuation?

No, it is grammatically incorrect. The phrase requires a comma after "however" to ensure proper flow and readability. The correct form is "However, most significantly".

What is the difference between "however, most significantly" and "most significantly, however" in terms of emphasis?

While both phrases can be used to express contrast and emphasis, "however, most significantly" places more emphasis on the contrasting element introduced by "however", whereas "most significantly, however" emphasizes the significance of the point being made in contrast to what precedes it.