Sentence examples for however it is extremely difficult from inspiring English sources

However, it is extremely difficult to establish the validity of these links through systematic scientific inquiry, and, in any case, such environmental factors are not always associated with the disorders.

However, it is extremely difficult to deal with both effects jointly.

However, it is extremely difficult to perform such DCB fatigue tests without extensive fibre-bridging developing across the crack faces.

However, it is extremely difficult to derive an optimal stability bound with the explicit dependency on wave numbers.

However, it is extremely difficult to differentiate C. guilliermondii (Pichia guilliermondii) from members of the C. famata complex.

However, it is extremely difficult to design a perfect FDI method to efficiently monitor an industrial-scale process.

However, it was extremely difficult to identify ISV endothelial sprouts or filopodia in ultrathin sections as they do not appear to have a characteristic lumen and travel through a volume of at least 50,000 µm3 (estimated from confocal data).

However, since it is extremely difficult to demonstrate that intact RNPs are introduced into cells, differentiation between RNP recognition and naked RNA recognition remains elusive.

These observations have been largely made using muscle sections however, which makes it is extremely difficult, if not completely impractical, to examine all myonuclei in a given myofibre: the basic functional unit of skeletal muscle.

However, in practice it is extremely difficult to identify molecular subpopulations expected to respond to an investigational drug.

However, in practice, it is extremely difficult to identify farmers and veterinarians not complying with regulations, so this sanction is never actually applied.