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However, HA treatment had no protecting effect on CD44-knockout mice, suggesting a role for HA-CD44 binding in exerting the protective effects of HA [ 73].
We were unable to model S20 into the H3 structure; however, HA fusion inhibitors that are specific for group 2 HAs have been reported and are predicted to bind to a pocket near the same loop region in the group 2 HA structure.
However, HA in PRP-SF bioscaffolds comes from a natural HA source and has higher molecular weight than the described in those studies.
However, HA undergoes rapid clearance due to limited adhesion, which necessitates frequent instillation.
However, HA also exhibited an affinity for fast inactivated channels (KI = 2.5 μM) and shifted the V1/2 for activation in the depolarizing direction.
The combined treatment comprising biomaterial AF and NP repair was effective at increasing NP hydration from NP repair alone, however HA injections alone are sufficient to improve mechanical properties.
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Claire, however, has problems.
Conditions, however, have nosedived.
Macedonia, however, has stalled.
Times, however, have changed.
Many, however, have balked.
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