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In many organisms, how rapidly a gene evolves depends on how tightly connected its expression is to the expression of other genes; highly connected genes evolve more slowly.
Regarding the biological meaning: Clustering coefficient demonstrates how tightly connected any miRNA is to its neighbors in the miRNA-miRNA network; thus high clustering coefficient can mean that a gene is typically regulated by several microRNAs which can indicate the robustness of this control – malfunction of one miRNA or even several of them can be overpassed by the remaining miRNAs.
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The shortest path distance shows how accessible the network is; small values are desirable for a tightly connected network.
A typical problem is how to generate partitions of a network in order to establish clusters, groups of tightly connected units.
Synonyms are "collective, cooperative" and the most tightly connected, "joint".
Belgium is tightly connected with the European project and its institutions.
In the next few years, television became tightly connected to football.
And when everyone is more tightly connected, but not everyone is more tightly governed, small units can wreak large havoc -- the love bug.
Even for a country with a tightly connected elite, it is an unusually illustrious history.
These points are tightly connected.
In the aggregate, countries have become more tightly connected.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com