Sentence examples for how this lesion from inspiring English sources

How this lesion specifically affects mitochondrial function or iron metabolism is unclear but it has been proposed that pseudouridylation of small RNA's distinct from tRNA may affect mitochondrial function [10].

Not much is known about the biological consequences of the C4′-epimeric lesions with the exception of the studies assessing how this lesion affects DNA replication.

In Huntington's disease, mice carrying the pathologic genetic variant of the huntingtin gene are being used to understand how this genetic lesion causes degeneration of striatal neurons and to develop novel treatments for the illness.

The results are consistent with the reported mutagenicity of M1dG and illustrate how the lesion may affect replication events.

As the contrast type in T2*-weighted images strongly differs from that known from more conventional sequences, it is unknown how the lesion conspicuity on T2* weighted images compares with that in FLAIR and DIR images.

However, mechanisms by which myelin affects the phenotype of macrophages and how this phenotype influences lesion progression remain unclear.

In this study we aimed to determine whether myelin directs the inflammatory phenotype of macrophages by PPAR activation and how this phenotype impacts lesion progression in MS. We show that internalization of myelin and PSLs inhibit NO production by macrophages through activation of PPARβ/δ.

Currently it is unclear how these lesions form, and how protein aggregation and neuronal loss are connected [6].

Our conceptual framework for understanding how these lesions arise is based on studies in EAE.

Much is known about the immunological circuits that maintain established psoriasis lesions, but how these lesions initially develop is still unclear.

If it is accepted that hippocampal lesions disrupt the formation of such an association, it becomes important to identify precisely how the lesions are exerting their influence.