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As we have seen, our model predicts how substantial changes in systemic parameters and in pharmacokinetic and pharmacodynamic parameters of the anti-VEGF agent influence the concentration of free VEGF in the tumor following administration of the anti-VEGF agent.
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In addition, any statistically significant difference in population Healthy Days Measures can be interpreted as a meaningful change, but how substantial the change may be more easily comprehended by calculating the total days of change on a population level.
Despite the improvements that Mr. Louima acknowledged and that police and city officials are quick to emphasize, there exists a stubborn uncertainty among some about how substantial or lasting the changes might prove to be.
The Australian Law Reform Commission has recommended substantial changes to how it operates.
Whilst we have already made substantial changes in how we approach this, we have more improvements to make".
It will be years before many people experience substantial changes in how their health care is paid for or delivered.
Defense Secretary Donald H. Rumsfeld opened a six-day tour of Asia and the Pacific on Thursday, hinting at substantial changes in how American forces are deployed in the region.
Breakthroughs in smartphone materials, software and even batteries could lead to substantial changes in how smartphones look and function in the future.
At that time, it was compelled to make substantial changes to how its online login system,.Net Passport, stored addresses, ages and other personal details.
A9 Rumsfeld Begins Asia Visit Defense Secretary Donald H. Rumsfeld opened a six-day tour of Asia and the Pacific in Guam, hinting at substantial changes in how American forces are deployed in the region.
So Microsoft may well need to make rather more substantial changes to how Windows 10 goes about sucking up users' metadata in the coming months.
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