Exact(30)
In the past few years, however, empirical data have emerged from experiments that were specifically designed to tackle the question of how specificity is encoded by calcium.
Because most of the PRC complexes (except PhoRC) lack specific DNA binding components, an important issue is how specificity in recruitment to loci is achieved and what components are involved.
However, to date, there is no experimental support for a mechanism whereby specific miRNAs are loaded into MVBs for secretion; neither is it known how specificity is achieved in apoptotic bodies and shedding microvesicles.
Knowing how specificity is controlled, would allow to optimise this activity in an efficient way by means of enzyme engineering.
This work provides clues toward uncovering how specificity is achieved within the binding pocket of a polyspecific transporter that may open new possibilities as to how these transporters can be manipulated to bind a designed set of drugs.
Given that, such a large number of stimuli can activate NFκB, which in turn activates an equally large number of target genes, understanding how specificity generated within the framework of pleiotropic signaling is a major challenge.
Similar(30)
In order to facilitate more critical assessment, we have amplified the description in Methods of how specificities for each amino acid were determined.
Specificity: How specific were they about their existing plans that conflicted with your date invitation?
An important question is how such specificity is achieved despite relatively similar DNA-binding specificity.
These are the first examples of altered-specificity E2 E3 enzyme pairs and give further insight into how E2 E3 specificity is obtained.
From these experiments we conclude that, unlike Erf2, and Pfa3, Swf1 is specific and therefore an interesting model to study how palmitoylation specificity might be achieved.
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