In contrast with the general population, acquisition of B. pseudomallei in CF appeared to be more likely to result in chronic infection, which is problematic given how difficult it can be to eradicate this pathogen even with targeted antimicrobial therapy.
He is sympathetic to the fact that, naturally, people become involved when an issue affects them, but also sees how it can be problematic, stating: "When there was an issue with local tennis courts, some more affluent residents might turn up and campaign.
It can be quite problematic.
But over the last decade the mixed-use community that has been developed there and one like it in Austin, Tex., are seen as examples of how problematic properties can be successfully converted.
Winner Glenda Browne of Blaxland, Blue Mountains, Australia, documented how problematic the can be when alphabetizing.
Nuancing this celebration of plastics is the "scary case," with hair combs, belts, and shoes that are quietly self-destructing, and tell the story of just how problematic plastics can be as they age.
He argued that Goldacre had gone "over the top" in devoting a whole chapter (chapter five) to recommending large clinical trials using electronic patient data from general practitioners, without fully pointing out how problematic these can be; such trials raise issues, for example, about informed consent and regulatory oversight.
The first was selected because RNaseP is a ubiquitous endoribonuclease and the second to highlight how problematic models can be discovered.
Second, uncritical talk of the concept X can also lull one into a false sense of conceptual unity, that there is in fact a unary X. Machery's (2009) recent work indicates how problematic this can be.
It can be subtle, but I find it highly problematic.
