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Finally, we show how optogenetic feedback can be used to control firing activity in vibrissal somatosensory thalamus of rats.
In summary, we have performed a systematic and extensive investigation of how optogenetic feedback control can be used to precisely control neuronal firing levels during perturbations that strongly affect network excitability, across time scales ranging from seconds to days, both in vitro and in vivo.
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These results also suggest ways in which other neuroendocrine systems can be regulated, and demonstrate how optogenetic tools can discern their functional architecture.
Here, we show how optogenetic inactivation of superior colliculus neurons in awake monkeys leads to clear and repeatable behavioral deficits in the metrics of saccadic eye movements.
Using optogenetic feedback to control thalamic activity state during ongoing sensory input.
We next evaluated the functionality of optogenetic feedback control in the intact rodent brain.
Optogenetic feedback control could also be incorporated into more complex experimental contexts.
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We also discuss how optogenetic technology has been used to elucidate the biological significance of ultradian oscillations.
Right, average unit-to-unit cross-correlogram for both cultures (top, bin = 5 ms) and unit-to-unit synchronization structure for culture 1 (bottom) during optogenetic feedback control.
With the addition of closed-loop optogenetic feedback, excess inhibition reduces spike activity either during EC-dominant or CA3-dominant periods of the theta cycle.
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