Exact(2)
The issues that arise in all potential indications are: a) how long it is reasonable to wait to prove insufficiency of response to monotherapy; b) by what criteria that response should be defined; c) how optimal is the dose of the first monotherapy and, therefore, how confident can one be that its lack of effect is due to a truly inadequate response?
Amount of such iterations may vary a lot, from 1 to many per hitchhiking day, and is dependent on many factors: how optimal is the chosen route in terms of number and destination of cars, how far they will go, how fast they could drive on certain roads etc.
Similar(58)
This cohort of patients with neuromuscular disease was a heterogeneous population, and how optimal was the management of the dysphagia (as good clinical management can reduce pulmonary complications [ 9]), or was mouth care very diligent to prevent aspiration pneumonia secondary to infected saliva?
Consideration of how optimal institutions are structured when agents are non-rational and how they differ from their counterparts with rational agents.
Nurses play a pivotal role in this process, yet how optimal personal control is self-assessed and self-managed in Inflammatory Bowel Disease is poorly understood.
Phenotypic phase plane analysis is a constraint-based method which provides a global view of how optimal growth rates are affected by changes in two environmental variables such as a carbon and an oxygen uptake rate.
When respondents were finally asked how optimal stakeholder engagement could be achieved in the district, availability of resources was the most crucial factor mentioned: " The main problem which I see is the budget.
It describes how optimal designs can be constructed for paired comparison experiments involving several attributes.
The model addresses how optimal life histories are influenced by size-selective fishing gear.
A key area for consideration is determining how optimal conditions for learning can be created.
The results observed in speed reduction illustrate that no matter how optimal an innovation may be technologically speaking, it is only as effective as it is acceptable from a user standpoint.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com