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I love how it activates details, makes them clues to figuring out how this imagined universe functions and how we can use it to reconsider our own.
While DRAM is a known lysosomal protein, how it activates autophagy remains unclear.
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But he says that Arc would be more useful if more were known about how it is activated; otherwise it's difficult to know exactly what its activity represents.
The fully automated system was similar to the partially automated system in how it was activated and controlled; the difference was that the system also activated the steering, meaning that the drivers could release the steering wheel and did not need to do anything for the 45-min drive.
The JNK pathway is also activated by Notch working with Src42A or Src64B, but in a different manner to how it is activated by Mef2 and Notch, and with different consequences for cells.
They found that ATR can act in very different ways, depending on how it gets activated.
The activation of Ras: Ras is a critical ignition switch in signaling by cell-surface receptors (Vetter and Wittinghofer, 2001), and we seek to understand how it is activated at the membrane.
I've long been fascinated by the discipline, which shows how specific genes along an inherited spiral of DNA can be switched off and on by epigenes, which hover around DNA and determine how it is activated.
Desferrioxamine (DFO) is used to induce hypoxic condition in cell culture, however, it is not well illustrated how it could activate DNA damage pathway.
A better understanding of the role of NF-κB signalling and how it gets activated will increase our knowledge of the pathobiology of ageing and age related diseases.
Since high levels of Her2 are associated with aggressive forms of breast and ovarian cancer, understanding how it is activated could improve our understanding of these cancers.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com