Sentence examples for how interindividual variability from inspiring English sources

Population pharmacokinetic modeling is widely used to understand how interindividual variability in drug metabolism and physiology affects drug exposure and clinical responses.

"Even though there are hundreds of cell-based and cell-free models, and many chemicals are being sent through them, we really are not addressing the key point that's important for regulatory decision making, which is how much interindividual variability potentially exists in these responses," says coauthor Ivan Rusyn, a professor of veterinary integrative biosciences at Texas A&M University.

While steady-state clearance had moderate (41.5% CV) interindividual variability, time-dependent clearance was more variable, with interindividual variability of 122% for CLT and 201% for kdes.

The interindividual variability will prove a challenge; the question is how to match a distribution of models to a distribution of data.

Morphine is a widely used opioid for treatment of moderate to severe pain, but large interindividual variability in patient response and no clear guidance on how to optimise morphine dosage regimen complicates treatment strategy for clinicians.

There is first a general description of how to get started with the software via the PK, followed by PD and the inclusion of interindividual variability in parameters.

EA pharmacokinetics showed high interindividual variability.

CYP1A2 displays considerable interindividual variability, and this is due mainly to genetic factors [46].

Nevertheless, this parameter is the one which presents the highest interindividual variability.

Postsurgical rehabilitation presents a large interindividual variability, as suggested in literature [4, 45].

Interindividual variability in expression of these isoforms would cause interindividual differences in drug response, toxicity and cancer susceptibility.