Exact(2)
The crucial question is how equivalence of a country's system with the World Bank framework will be established.
(N.B. this notion is closely related to how equivalence trials are currently designed [ 27]).
Similar(58)
Figure 3 illustrates the highly significant difference (P<0.0001) in PD profiles of two generics from very well reputed makers, one destined to clinical use (GNT-Abbott) and the other to experimental use (GNT-Sigma), with GNT-S Plough; all three products had the same batch studied in vitro and in vivo, illustrating how pharmaceutical equivalence cannot predict therapeutic equivalence.
First, how can equivalence limits for GMO mean characteristics relative to reference mean characteristics be defined given that no generally agreed equivalence factor (such as 1.25) exists?
In Watson's words: "Immediately [Crick] caught on to the complementary relation between the two chains and saw how an equivalence of adenine with thymine and guanine with cystosine was a logical consequence of the regular repeating shape of the sugar-phosphate backbone".
Proponents of calibration arguments do not claim to give an account of how the equivalence relation is determined.
The following codes show how an equivalence for the single machine model with typical steam turbine-governor model IEEEG1 is obtained.
The chapter also discusses how the equivalence between Ursell number and modulus can be used to improve the understanding of nonlinear wave data and how new numerical methods for nonlinear Fourier analysis help to compute the nonlinear cnoidal wave spectrum of a measured wave train, even when the physics is extremely nonlinear (i.e, soliton dominated).
Figure 4a) shows how the equivalence parameter ω is distributed in a library along a section of the gene (np5) and which probes would be removed by the different thermal filtering criteria (For the sets of filtered probes see Text S2).
Secondly, how should equivalence limits be estimated given that appropriate data from field trials will describe typical biological variation rather than the maximum allowable variation?
The CNAAB3005 illustrated how apparent equivalence can be the consequence of a dilutional effect of comparing 2 treatments in the ITT (527 patients) when only 54% of the patients where on-treatment.
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