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Overall, our investigation provides important insight into how different layers of epigenetic information are linked to gene regulation.
We thus address the key question of how different layers of gene expression affect corresponding levels of protein and mRNA in a biologically important, dynamic system.
High-throughput ('-omics') measurements of macromolecule variations in the cell offer the possibility to comprehensively understand how the cellular processes are regulated and to reveal how different layers of control are coordinated in producing a physiologically coherent response.
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Because of how siloed these functions were and how many different layers of command Tom had to go through, it was nearly impossible to bring these units together when needed.
But biodiversity isn't simply how many different kinds of greens I can grow, but how many different layers I can build into my food web.
This is the first mechanistic view of how different envelope layers talk to each other as they grow and constrict during cell division in Gram-negative bacteria.
"It's largely about texture," he said, "and how the different layers work within it.
It has been incorporating geology into the game, making it easier to understand how the different layers of rock join, fold, overlap, fault or dissect each other.
Figure 1 shows how the different layers can be organized in practical cases.
"It all depends on what kind of questions are being answered, and what's that valid sample size, and how many different layers of questions do we need to ask to get the right answers," Holman said.
The nucleotide distribution in the sequences of organisms of different complexity is important for understanding how the different layers of regulation are recruited.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com