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As expected, genes assigned to the metabolism of carbohydrates, amino acids and proteins were more numerous since they are related to the housekeeping functions of all living organisms.
This is not surprising given that the housekeeping functions of mammalian cells are relatively well conserved.
However, deletion of most of the non-consensus repeats does not affect the housekeeping functions of mammalian cells, but it does impair activator-induced gene transcription [ 18, 19].
These GO terms represent housekeeping functions of every cell type, but can also be related to the cellular homeostasis of ESCs.
The general existence of the conversion enzymes suggests the possibility that conversion might be an "accidental" consequence of the housekeeping functions of the other enzymes.
Increasing evidence also suggests a non-cell-autonomous role of autophagy in cell death, which extends the housekeeping functions of autophagy to a multicellular level.
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Conservation of microsynteny (where possible to ascertain, i.e., in Drosophilidae) and of the structural organization of the gene strongly suggest that the genes maintaining the NRG element are the direct phylogenetic derivatives (true functional orthologs) of the ancestral insect genes responsible for the basic housekeeping function of energy production.
These screens are clearly a valuable means to assess the housekeeping function of Smn.
The dichotomy between the ubiquitous housekeeping function of Smn and the very specific neuromuscular SMA phenotype raises the question whether Smn functions differently at the neuromuscular junction (NMJ) than in other tissue types.
The lack of a signal peptide in full-length clones suggests housekeeping function of these peptides.
Furthermore, PRS2,4 and PRS3 show constitutive low expression levels, suggesting a housekeeping function of these genes [ 4].
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