Conservation of microsynteny (where possible to ascertain, i.e., in Drosophilidae) and of the structural organization of the gene strongly suggest that the genes maintaining the NRG element are the direct phylogenetic derivatives (true functional orthologs) of the ancestral insect genes responsible for the basic housekeeping function of energy production.
They seem to restore the normal housekeeping function.
However, these conserved proteins, derived from a single gene, are expressed in numerous tissues indicative of a more generalized housekeeping function in addition to their tissue-specific roles.
"The difficult decision to outsource the housekeeping function at our Boston properties was made in response to the unprecedented economic challenges those hotels are facing in the current business environment," Hyatt said in a statement.
Considering DYNC1I2 may play housekeeping function (Myers et al., 2007) and neurites of cultured neuron grow fast before 7 days in vitro (DIV7) (Dotti et al., 1988), we selectively knockdown DYNC1I1 expression at DIV6 in rat primary hippocampal neurons.
Based on its pattern of ubiquitous expression, OsPrxIIC may have a housekeeping function through its association with ROS-processing enzymes (including glutathione peroxidase and thioredoxin) or else in ubiquitin-related processes.
These screens are clearly a valuable means to assess the housekeeping function of Smn.
Given that Psmc6 serves such a housekeeping function, it is surprising to observe variation in expression levels.
Although widely expressed, the increased cerebellar expression of CNTN1 suggested a more targeted role than a housekeeping function.
These results support the hypothesis that Ppt1 acts as a metabolic enzyme with housekeeping function with relatively little need for high RNA concentration and/or turnover.
Also, owing to their housekeeping function, they are highly conserved among different H. pylori strains irrespective of their genotypes and thus can serve as ideal immuno-diagnostic candidates.
