Overall, our study provides insights into transcription regulation by three-dimensional chromatin interactions for both housekeeping and cell-specific genes in human cells.
Furthermore, genes in cluster 1 are highly expressed and associated with housekeeping functions and cell growth (Additional file 1: Figure S6, S7).
It is clear that HSP90 plays an important role in parasite housekeeping, metabolism, and cell cycle, particularly considering the huge number of client proteins that are under HSP90 control.
The decline in autophagy with aging impairs cellular housekeeping and exposes cells to the risk of inflammasome activation.
These factors impair cellular housekeeping and expose cells to higher risk in many age-related diseases, such as atherosclerosis and type 2 diabetes.
In QSCs, nearly 50% of annotated genes in the mouse genome, including nearly all housekeeping genes and cell-cycle genes, were marked with H3K4me3 at their TSSs.
Autophagy occurs at a basal level in every cell as housekeeping and plays key roles in cell development, immunity, tissue remodeling, and orientation with the surrounding environment.
Peptidases with clear housekeeping functions in growth and cell wall remodeling are omitted from Table 2. Extracellular peptidases have been detected in culture supernatants of Frankia strains [ 6, 39].
Such cell cycle disruption is associated with genomic instability, due to mutations and chromosomal aberrations that disrupt critical housekeeping functions, including DNA repair and cell cycle checkpoints.
Although the number of assigned mRNA transcripts detected by this approach is quite small, we could identify some genes being expressed in all samples such as those encoding ribosomal proteins and basic housekeeping machinery like elongation factors and cell division proteins.
