It was evident from these data that OLM provided consistently strong BP-lowering properties over 24 h and during the last few hours of the dosing interval [ 6].
Telmisartan/HCTZ has demonstrated superiority over losartan/HCTZ in patients with essential hypertension in terms of 24-hour ambulatory BP, including a BP-lowering effect during the last 6 hours of the dosing interval [ 92, 97, 98].
Given once daily, telmisartan 80 mg significantly reduced 24-hour blood pressure compared with losartan 50 mg, with especially large benefit in the last 6 hours of the dosing interval [ 18].
A previous pooled analysis of two studies in patients with uncomplicated hypertension showed that telmisartan 80 mg provided SBP reductions in the last 6 hours of the dosing interval and in the 24-hour mean that were superior to the equipotent valsartan 160 mg (by 2.7 and 2.0 mm Hg, respectively) [ 11].
Menvielle (1979) showed that the K index is a proxy of the magnetic energy density related to the geomagnetic activity, because the time scale of the observed geomagnetic variations is less than the 3-hour length of the interval for which K is measured.
To study the diurnal dependence, we calculated the relative occurrence rate over each hour of the diurnal interval as was done by Kotake et al. (2007) and Otsuka et al. (2011), who used the GPS total electron content (TEC) maps over Japan (GEONET) to determine MSTID parameters.
Fifty hours was the interval between receipt of a blood sample and identification of a provisional molecular diagnosis, provided that the diagnosis was readily apparent upon variant filtering.
Bolus tocolysis involved an initial dose of 10 mcg every 3 min with doubling the interval after contractions stopped (assumed after 1 hour), and further doubling of the interval after 12 and 24 hours.
Quotes chosen by Google to illustrate Steinbeck's genius include: "In the souls of the people the grapes of wrath are filling and growing heavy, growing heavy for the vintage"; and "It is the hour of the pearl – the interval between day and night when time stops and examines itself".
Similarly, for the end of the maximum exposure period, we subtracted the minimum incubation period (24 hours) from the midpoint of the interval containing onset of the first case (am, May 30).
