The mean area under the concentration-time curve from time 0 to 72 hours, volume of distribution and total clearance were 2514 ± 212 mg/hour per l, 19±± 6 l and 62±± 5 ml/min, respectively.
Figure 2 shows the usual weekly hours of work distributions (in 4-hour bin widths) both before and after the 1988 reform.
Further, we assume that their hours of work distributions are uniform apart from two peaks at full-time jobs with 35 and 40 weekly hours of work, respectively, and one peak at part-time jobs with 20−30 weekly hours of work.
32 In a study of patients with PD, rasagiline had a half-life of 1.34 hours, median time to Cmax of 0.5 hours, and volume of distribution of 182 L. 34 Rasagiline is metabolized via CYP1A2-mediated dealkylation to 1-R-aminoindan.
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The half-life was 2.2 hours, the volume of distribution was 1.03 l/kg, and the clearance was 0.33 l/kg/hour.
AUC0 72 h, area under the concentration time-curve from time zero to 72 hours (mg/hour per l); CLtot, total clearance of ceftazidime (ml/min); Css, steady-state serum ceftazidime concentration (mg/l); T1/2, elimination half-life (hours); Vd, volume of distribution (l).
