Sentence examples for hour variation in from inspiring English sources

Twenty-four hour variation in clearance and oral bioavailability as well as the increase in absorption rate constant can be explained by several physiological factors.

Only one CRG, rev-erba, showed 24-hour variation in fetal rat liver (E20) [42], consistent with the lack of rhythms in E18-19 fetal mouse liver reported here.

Figure 4 shows the 24-hour variation in bioavailability and in clearance of the final model.

The aim of this study was to evaluate 24-hour variation in the pharmacokinetics of the CYP3A substrate midazolam.

Alternatively, 24-hour variation in bioavailability was estimated by implementing different multiplication factors on this parameter for each of the six timepoints of administration.

In the current study, we aimed to evaluate 24-hour variation in the PK parameters of midazolam after semi-simultaneous oral and i.v. administration in healthy volunteers.

Circadian rhythm exhibits a 24-hour variation in physiological processes and behavior, such as hormone levels, metabolism, gene expression, sleep and wakefulness, and appetite.

30 However, our finding of 24-hour variation in oral bioavailability of midazolam is supported by chronopharmacokinetic studies of other CYP3A substrates, such as nifedipine, tacrolimus, and cyclosporin.

43 By using six different timepoints of oral and i.v. midazolam administration, 24-hour variation in absorption parameters as well as clearance could be accurately identified.

15 Hence, most chronopharmacokinetic studies about i.v. midazolam are in line with our findings of a relatively small 24-hour variation in midazolam clearance.

White adipose tissue and its constituent adipocytes are both circadian rhythmic, and many adipokines exhibit 24-hour variation in plasma concentrations [ 49].