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The change of the average hydrodynamic particle size during the polymerization depends, especially within the first hour, strongly on the monomer equilibration time.
For both STAT-5 and JAK-2, phosphorylation in UT-7 cells served as positive controls for the activation of classical EPOR downstream signalling: Withdrawal of rHu-EPO for 1 hour strongly reduced the phosphorylation of STAT-5 and JAK-2 while the signalling components were strongly phosphorylated upon treatment with rHu-EPO (10 U/ml for 15 minutes).
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Pretreatment of zebrafish larvae with MβC for four hours strongly inhibited endocytic uptake of AM1-43 by enterocytes (Figure 7E).
The relatively subtle but distinct metabolic changes seen in response to drug treatments allied with the lack of overt cellular changes at 24 hours, strongly imply that we have measured genuine drug responses and not secondary changes within the metabolome occurring after drug induced changes in cell behavior.
As positive control, the Src inhibitor E804 (10-7 M, 24 hours) strongly decreased the phosphorylation of the tyrosine kinase (Fig. 5C).
Although the effect of sunshine was not significant in a previous study [ 36], we found that sunshine hours strongly influenced cycle volume particularly in winter and spring.
The pattern of stem water potential occurring during the afternoon hours strongly affects shoot growth rates in the field (Berman and DeJong, 1997).
The employment-related psychosocial work environment, particularly workplace relationships, employment security and degree of control over hours, strongly affected participants' mental health.
From Additional file 2, the sequestration of IGF1 by secreted IGFBPs was not significant until after 4 hours, strongly suggesting that the observed depletion in Figure 2A was the result of cell-mediated endocytosis.
As expected, reward related long-term memory for the scenes (after 24 hours) strongly correlated with activity of MTL, ventral striatum, and substantia nigra/ventral tegmental area (SN/VTA).
6 Nonetheless, epidemiological evidence of reductions in motor vehicle crashes, 7 needlestick injuries, 8 and mental illness 6 since the advent of regulations on working hours strongly suggests that trainees are generally now less tired than before.
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