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While there is continuing debate on the appropriateness of medical helicopters, work by Branas and colleagues [ 9] has found that nearly 82 million Americans rely on access to helicopters to reach tertiary care within the 'golden hour' of time-dependent disease.
This observation is in line with prior findings of time-dependent pattern of leukocyte recruitment in rat CLP-sepsis with increased leukocyte adhesion after seven hours and normalized values after 20 hours [ 55].
We selected transcripts with > 2 fold-change (2-FC) between the baseline and later timepoints from each heart to evaluate the change in gene expression during the 24 hours of autolysis in a time dependent manner.
Incubation of RA FLS with IL-1β for 72 hours resulted in a time dependent increase in the secreted levels of TIMP-1.
Sensory irritation induced by FA is considered concentration dependent and essentially not time dependent after few hours of exposure (Paustenbach et al. 1997; WHO 2010; Wolkoff and Nielsen 2010; Golden 2011).
Figure 2(c) shows that inhibition of S6K1 activity was stringently time dependent with more than 80% inhibition observed at 4 hours of the drug exposure.
The induction of matrix metalloproteinases (MMPs) was time dependent, with effects primarily seen after 36 hours.
We observed a time dependent loss of MMP which was maximum at 72 hour post-transfection in Neuro-2a cells (Fig. 2A, B).
This concentration was subsequently used to study the time dependent uptake of oxLDL and nLDL for up to 4 hours.
The effect of doxorubicin on B7-H1 dowasegulatime was time dependent reaching a 90% inhibition after 72 hours incubation.
Early time points (0 4 hours), circles; late time points (8 48 hours), triangles; time-dependent metrics, filled squares.
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