Conclusion: The fetal urine production rate is augmented after acute maternal oral hypotonic rehydration after 4 hours of fluid deprivation.
The hourly fetal urine production rate was determined by linear regression analysis of the calculated bladder volumes versus time and was initially determined after a period of 4 hours of fluid deprivation.
Compared with the initial hourly fetal urine production rate after 4 hours of fluid deprivation, the hourly fetal urine production rate showed an increase of 63.2% after hypotonic rehydration, from 38.2 ± 16.3 mL/h to 62.4 ± 34.6 mL/h (mean ± SD).
The review examined the first 72 hours of fluid resuscitation in patients with ≥15%TBSA burns who were admitted less than 24 hours post burn injury.
Administration of LPS was followed by 4 hours of fluid resuscitation with an infusion of intravenous 0.9% saline at 4.3 ml/kg/h.
After 24 hours of fluid resuscitation, almost 90% of patients in the PRISM study were still hypovolemic and most had developed marked generalized peripheral edema.
Renal function was also unrelated to volume status on admission; indeed, after 24 hours of fluid resuscitation, the more hypovolemic patients had lower plasma creatinine concentrations [ 25].
In the patients with significant renal impairment still passing urine, 50% had an increase in plasma creatinine despite 24 hours of fluid resuscitation.
The creatinine concentration decreased during six hours of fluid infusion at 1 litre-per-hour in simulated patients, irrespective of fluid type or extent of change in GFR (from 0%to6767% reduction).
cPost-initial resuscitation in the Vietnamese Hemodynamic Study (VHS), post-6 hours of fluid resuscitation in PiCCO-guided Resuscitation in Severe Malaria (PRISM) except plasma creatinine which was assessed after 24 hours.
