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Of the 12 dogs with Cmax at 12 hours, the reported Cmax ranged from 51%to98%8% of the 12 hour concentration: 5 were at > 90%, 8 were > 80%, 10 were > 75% of the 12 hour concentration.
Table 1 shows the distribution of the mortality by cause, together with the distribution of the weather variables and PM2.5 that had a median 24 hour concentration of 34μg/m.
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The hourly data also showed that afternoon rush hour concentrations were frequently over-predicted.
All the babies with high 24-hour concentrations then had "random" values above this cut off line, i.e. its positive predictive value for babies with 24 hour concentrations <1 mg/l was 100%.
24 hour concentrations of >1 mg/L were considered high, and an indication to extend the dosing interval.
Equally those with less good renal function would have had a lower clearance of gentamicin and high "random" and 24 hour concentrations.
In our study, we did not observe any effect of malnutrition on 2 hour concentrations, Cmax, Tmax, and AUC0 4 of isoniazid, rifampicin, pyrazinamide or ethambutol, even with enhanced dosing.
If this regression line were to be used as the cut off for predicting 24 hour concentrations, its sensitivity would be 84% (16/19), positive predictive value 64% (16/25) and specificity 71% (22/31).
Twenty-four-hour concentration to time plots of three 3- to 4-week-old neonates showed a half-life of 23.44 ± 3.57 hours.
A young accompanist who worked with Szigeti told me that two hours concentration wouldn't get them beyond the first three bars of a sonata--so much analysis and ratiocination went into his practice.
Based on these equations, the 24-hour concentration was updated daily in the simulation model.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com