Sentence examples for hotspots of interaction from inspiring English sources

Thus, we have shown that by focusing diversity to the hotspots of interaction a library with improved hapten-binding ability can be created.

By high-resolution mapping of intra- and interchromosome interactions, Rickman et al. [ 80] demonstrated that ERG binding is enriched in hotspots of differential chromatin interaction.

The best estimates for N w were obtained by considering 'hotspots' of interactions.

For all pairs of interaction hotspots, the shortest paths on a molecular graph of the ligand, between two interaction hotspots, are identified.

In the building conformation step, the time depends on the number of pairs of interaction hotspots within the defined distance range.

Our method is composed of three steps: pre-processing (Section 2.3), prediction of interaction hotspots (Section 2.4), and building ligand conformations (Section 2.5).

The computation times required for the pre-processing step, the prediction of interaction hotspots, and the building ligand conformations are shown in Table 1.

Since ERG binding strongly associated with hotspots of differential chromatin interactions, an upregulation of ERG when fused to TMPRSS2 upon androgen stimulation consequently leads to altered regulation of transcription events.

Turkey is a crossroads of major population movements throughout history and has been a hotspot of cultural interactions.

The resulting fingerprint of interaction displays hotspots in the third transmembrane α-helix and the second extracellular loop selectively bound by most 5-HT2C inverse agonists.

First, we observed that both methods found significant epistatic effects between Chromosomes 1 and 5. Recall that in our previous analysis of the hotspots, this interaction was discussed (see hotspot 1 in Table 1).