Exact(7)
This location coincides with the position of the body composition QTL hotspot (Figure 1B).
Indeed, highly oncogenic mutations BRAF-V600E, KIT-D816V, and PDGFRa-D842V belong to the largest mutational hotspot (Figure 6B).
This tropical rain forest retains considerable portions of natural vegetation, which represent the best-preserved part of the Tumbes-Choco-Magdalena hotspot (Figure 5).
To demonstrate the specificity and sensitivity of the DNA strand breaks capture, we first used a plasmid as a model representing a simple defined hotspot (Figure 2 and 3).
We designed 6 primer sets (t2, t4, bbt56, bt56, t56, in14) to analyze RAD51 binding in a region around the approximately 20 base pairs (bps) translocation breakpoint hotspot (Figure 3A and Figure S8) [5], [5].
To test our proposed location for the Lrp5/6 binding site, we generated the disease-associated Norrin mutant R121W (Arg121 is a mutational hotspot; Figure 2 figure supplement 2).
Similar(53)
Thus we now have landscape- and regional-scale tools capable of identifying and quantifying potential hotspots (Figure 7) of denitrification.
Although there is no unified network architecture for mobile hotspots, Figure 1 illustrates a typical architecture based on existing wireless technologies [1, 2].
Seven of the 30 sampling sites were in known invasion hotspots (Figure 1) [27], [27] of the Great Lakes.
The insertion of kDNA at unique CSB-similar AC repeats shared by both minicircles and retrotransposable elements suggested integration hotspots (Figure 3C).
Tiger consumption prevalence also varied significantly ((F6,1879 = 52.12, p<0. 001) depending on the city, with Chengdu and Shanghai being the consumption hotspots (Figure 2).
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