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In general, PSF correction overestimated the hot sphere values.
Fig. 5 a e Recovery coefficients as a function of hot sphere size from five different hot sphere activity concentrations across all sites.
The COV for each sphere size and hot sphere activity concentrations are shown in Table 3.
The b/w image (top) shows the original image (hot sphere plus warm background).
In general, PSF increased hot sphere contrast, but not cold sphere contrast.
Following application of the appropriate SUVref filters, this variation reduces to 0.38 to 0.43 for the 10-mm hot sphere and 0.93 to 1.04 for the 22-mm hot sphere.
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The six spheres (10-, 17-, 17-, 28-, 28- and 37-mm diameter) were filled to produce a hot sphere-to-background ratio of either 4 1 or 8 1.
For the phantom studies, a 68Ge-filled NEMA IQ phantom, with a total activity of 116.37 MBq and a hot sphere-to-background ratio of 4 1, was acquired 15 times with a frame duration of 9 min each on a 3-ring Biograph mCT with 64-slice computed tomography (CT) and 4 × 4 mm lutetium oxyorthosilicate crystals (Siemens Healthcare, Molecular Imaging).
The 1 4 background-to-hot sphere ratio showed similar results (data not shown).
The higher background-to-hot sphere ratio (1 4) showed a clear image improvement with the combination of TOF and PSF in the mCT reconstructed data (Fig. 4b).
For reconstructions without PSF or TOF, three iterations were found optimal for both systems for the higher background-to-hot sphere ratio.
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