Sentence examples for host-derived molecules from inspiring English sources

The use of host-derived molecules rather than materials derived from bacterial cell walls or plants offers advantages in terms of rational design of adjuvants.

This chapter describes the use of various host-derived molecules (or antibodies directed against them) as immunological adjuvants for prophylactic and therapeutic vaccines.

Along with these advantages of host-derived molecules lie some inherent dangers, the most obvious of which is the possibility of generating autoimmune responses against the host molecule used as an adjuvant in the vaccine.

The Nlrp3 inflammasome is activated by pathogen-associated molecular patterns [49] and host-derived molecules, such as DNA, which indicates cellular damage and cell death, so-called damage-associated molecular patterns [50].

During feeding, ticks take up host-derived molecules as complement and other blood components.

Although antibodies normally target foreign molecules, under some circumstances they may be raised against host-derived molecules.

Therefore PF4 is a unique example of a host-derived molecule with direct plasmocidal activity.

It contains components of circulating blood, local tissues and most importantly, host-derived inflammatory molecules [ 16, 17].

Numerous host-derived signaling molecules are known to have instructive roles in tumor promotion and suppression, resulting in a complex crosstalk between tumor and various stromal cells (1 2 3).

A comparison between trypanosusceptible and trypanotolerant animals allowed identification of two host-derived pleotropic molecules, Galectin-3 and macrophage migration inhibitory factor (MIF), which are strongly upregulated in T. brucei infected mice.

Individual NLRs specifically recognize microbial derived non-self products such as peptidoglycan-derived molecules [8], [9], viral dsRNA, bacterial toxins, as well as host-derived danger-molecules like uric acid crystals [10] [12].