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We have purposefully selected NKF community dialysis centres across Singapore to ensure geographical representation, however, certain dialysis centres were not approached due to the lack of facilities to host the intervention or distance from other dialysis centres with such facilities.
Although random selection of dialysis centres would have been preferable this was not an option due to the lack of facilities in their excluded dialysis centres to either host the intervention in situ or their considerable distance to other dialysis centres with available facilities.
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Collaborators at local settings are thanked for hosting the interventions.
A website (www.downyourdrink.org.uk) was constructed to host the DYD intervention and other components required for the trial.
Crucially, according to official OECD guidelines, the host country must request the intervention.
The only actions needed and costs associated with the implementation, adoption and continuation are recruiting participating schools or individuals, hosting the website, preparing the intervention for implementation after the research has been conducted, and keeping the information up-to-date.
The Patient Safety First website was used to host information on the interventions and on the programme more generally.
However, challenge with sublethal levels of ZAIRE virus resulted in a fully-symptomatic disease that was successfully resolved solely by the immune response of the host without medical intervention.
We gathered strong evidence indicating that CD4+ T cell help of CD8+ T cells requires the intervention of third party host APCs, and that this effect is CD40-dependent [20].
In this section, we focus on peptides whose main established functions provide a physiological attribute to the plant, but it should be noted that a peptide might participate in a defense strategy against infectious agents, while being at the same time a component of a metabolic function of the host plant without intervention of an infective agent.
The economic evaluation will be assessed from a societal perspective, thus including the intervention costs (such as costs for building the intervention, costs for hosting the website), the costs of formal and informal health care (TIC-P), and the economic costs due to productivity losses in paid and unpaid work in the four weeks preceding the trial (PRODISQ).
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