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"Once you understand host sensitivity to a disease, you can design countermeasures to ward it off," she explains.
Modifications in the glycosylation of FimH receptor proteins on eukaryotic cells may alter the host sensitivity to UTI causing strains.
Such mechanisms are characterized by genotypic variation in host sensitivity and pathogen virulence.
Ultimately, the identification of the genes underlying host sensitivity loci will allow molecular and biochemical characterization of host-pathogen interactions.
However, the ability to develop genetic markers diagnostic for allelic state at the corresponding host sensitivity loci provides additional benefits.
First, it allows workflows to be streamlined, as wheat breeders now routinely use genetic markers, allowing host sensitivity markers to be easily incorporated into current practices.
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Compatible SnTox2- Snn2 and SnToxA- Tsn1 interactions are additive in their effects for susceptibility (Friesen et al. 2007), showing that in contrast to the classical gene-for-gene model, the presence of two effector-host sensitivity gene interactions results in more disease than one interaction alone (Friesen et al. 2008).
The host-sensitivity of the assay was determined as 1.00 while the host-specificity of the assay was 0.96.
To further characterize how other biological variables influenced the host's sensitivity to CrPV infection, we determined how genetic background, sex, age, and temperature affected the death kinetics of flies infected with CrPV.
Similarly, an independent research team has shown that over-expression of the Staphylococcus aureus cysM (cysteine synthase) gene in E. coli also confers increased resistance to tellurite, and that inactivation of this gene in its natural Gram-positive host confers sensitivity to tellurite [46].
Nonetheless, variation in host probe sensitivity may introduce another source of error in our findings.
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