Notwithstanding, these results provide evidence that Y. pestis has evolved, at least in part, to limit host innate immune cell apoptosis/cytotoxicity and further demonstrate the importance of understanding host innate immune cell fate following interaction with Yersinia.
Understanding the intricacies in the strategies acquired by a pathogen to remodel its host-cell machinery for successful colonization and persistence within the host requires understanding of protein protein interactions across the host and the pathogen.
Jannini suspects that attitudes toward same-sex desire can be a key to understanding a host of psychological issues, and recommended that researchers focus on how to prevent the development of homophobia.
Indeed, in a highly influential book, Timothy Williamson (2000) argues that knowledge is unanalyzable and is a concept that should be employed in understanding a host of other interesting epistemic concepts, including the concept of evidence.
This TD theory of dopamine provides a precise computational foundation for understanding a host of behavioural and neural data.
Development of this technology for a wide range of hosts requires deep understanding of transposition mechanisms of a variety of elements.
Despite the importance of understanding host-pathogen interactions at the epithelium, no immunocompetent vertebrate model has been used to visualize these dynamics non-invasively.
Lack of understanding of host nation language and cultural practices, and how these may impact on deployed forces, also increases the uncertainty (which norms and practices are acceptable in the host culture, and which are not?).
In part II of the interview below, Sternberg and host Chris Dixon discuss the importance of understanding the respective roles of the team and keyed in on the evolving role of the businessperson.
This review summarizes the current state of understanding of host genetic factors predisposing to HAND in light of past challenges and suggests some priorities for future research to advance the understanding and clinical management of HAND in the cART era.
It is to be expected that an integration of efforts from immunology, genetics, microbiology and systems biology will represent the novel level of understanding of host defense against fungal (and other) pathogens, improving the outcome of these severe infections.
