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G4 structures are hypothesised to interfere with replication of DNA and be involved in a host of regulatory functions including gene expression, genome stability and telomerase activity [ 24- 27].
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Such a pattern of moderate degradation of regulatory functions in host-restricted bacteria is most likely due to the accumulation of deleterious mutations by genetic drift, which also causes other moderately maladaptive consequences, including accumulation of deleterious amino acid substitutions and loss of adaptive codon biases [36], [42], [43].
The balanced gene groups are enriched for a multitude of regulatory functions and indicate a stronger sensitivity to gene dosage effects for the main regulatory networks.
Deletion of 18 open reading frames (ORFs) implicated in the pathogenicity and virulence of Orthopoxviruses, as well as in host-range regulatory functions involving the replication competence of these viruses, resulted in its attenuated phenotype [22].
Related cytotoxins in E. coli and C. difficile act by glycosylating small GTP-binding proteins of Rho and Ras families, inhibiting the host signalling and regulatory functions [ 42], lymphocyte activation [ 43] and by blocking the induction of IFN-γ.
The stable intracellular niche in host insects allows the loss of several regulatory functions of endosymbionts.
In response, we've had a host of regulatory reforms designed to curb executive pay.
We thus adopted the alternative strategy to investigate the host immune-regulatory function of NdpA by overexpressing it in K. pneumoniae.
SETX performs a number of RNA regulatory functions, including maintaining RNA transcriptome homeostasis.
This allows GREAT to generate hypotheses about the regulatory functions of the set of genomic regions.
Based on this analysis, WRKY33 appears to have a prominent repressive role on the transcription of many specific host genes indicating a negative regulatory function of WRKY33 in mediating immunity to this pathogen.
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