Scientists at Advanced Cell Technology in Worcester, Mass., say they have created 24 cloned cows that are normal in every way, an assertion that challenges the widely held view that cloned animals are prey to a host of defects.
Mutations in WAS gene hamper cell migration, signalling and activation causing a host of defects leading to eczema, micro-thrombocytopenia, recurrent infections, autoimmunity and increased tendency to develop lymphomas.
"Even iconic buildings, as Stirling buildings undoubtedly are, suffer from a host of minor defects which is forgivable.
If we prohibit incest on the grounds that it risks producing "defective" children, we must also prohibit reproduction by haemophiliacs and the carriers of a host of other "defects".
The disease, also known as German measles, usually causes only mild fever and rash in adults and children, but can be devastating to a fetus, causing stillbirth or a host of birth defects, including developmental disabilities, deafness, heart problems and cataracts.
By knocking down the expression of Parp3 in zebrafish embryos, we readily observed a host of developmental defects within the first 48 hrs after fertilization consistent with impaired regulatory networks at the neural plate border, a region formed at the interface of the neuroectoderm and the non-neural ectoderm in the hindbrain of early embryos.
The major aim of this study is to investigate the OH-defect inventory of orthopyroxene as major host of OH-defects in upper mantle minerals as a function of pressure and bulk composition.
In humans, NKX2-5 is one of the most commonly mutated single genes in congenital heart disease (CHD), with dominant alleles causing atrial septal defect and atrioventricular conduction block most commonly, and a host of more severe defects at lower penetrance (Elliott et al., 2010).
Online dating suggests that "on the internet, nobody knows you're a perpetual underachiever with a host of complex personal defects" may be more apt.
These have been trying times for GM, which last year had to recall nearly 27 million domestic cars and trucks and another 3 million overseas because of a host of dangerous engineering defects.
Some of the most well-studied avian genetic developmental mutants have been the talpids (talpid, talpid and talpid ): three independently discovered, naturally occurring, autosomal recessive, lethal mutants characterized by pre-axial polydactyly, craniofacial anomalies and a host of other developmental defects (Abbott et al., 1959; Ede and Kelly, 1964a, b; MacCabe and Abbott, 1974).
