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A key factor of M.tb pathogenesis is its ability to survive in host macrophages.
The virulence of Brucella is essential for survive and multiply in host macrophages.
The disappearance with time of host macrophages indicates a life-span, under the conditions, of approximately 81 days.
Mycobacterium tuberculosis (Mtb), the causative agent of TB, mainly resides in host macrophages and modulates their cellular physiology to support its own growth and duplication.
2. Németh K, et al. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2 -dependent reprogramming of host macrophages to increase their interleukin-10 production.
Recently, Wang et al. demonstrated that miR-155 is involved in autophagy, an essential process of mycobacterial killing in host macrophages [11].
These compounds were found to be active against Dormant and active stage MTB under both in vitro as well as within THP1 host macrophages.
In addition, the migration of host macrophages and multinucleated giant cells into the scaffold was also found to influence the vascularization of the biomaterial.
Yersinia pestis is a facultative bacterium that can survive and proliferate inside host macrophages and cause bubonic, pneumonic and systemic infection.
This study demonstrates that scaffolds for tissue engineering can be designed to harness the angiogenic behavior of host macrophages towards scaffold vascularization.
As in human TB, the microbe grows within the host macrophages, can mount life-long chronic infections and produces granulomatous lesions in target organs.
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