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Temperate viruses can directly affect host gene pools by stable colonization.
To address the effect of host gene readthrough, we used homologous recombination to insert HIV-1 genomes in either orientation into an identical position within an intron of an actively transcribed host gene, hypoxanthine-guanine phosphoribosyltransferase (HPRT).
This study aimed to evaluate the effect of dendritic cell (DC) vaccination against HIV-1 on host gene expression profiles.
Therefore, it is possible that integration of retroviral DNA will affect host gene expression and disrupt normal cellular functions.
The self-splicing activity of the RNA transcript allowed the element to have minimal impact upon the host gene.
MIRHG2/BIC is the host gene of miR-155.
Its host gene, Tmem49, is not upregulated in Dgcr8 or Dicer knockout ES cells.
Here, we evaluated if intragenic L1 hypomethylation influences their host gene expression in cancer.
This conclusion is supported by microarray comparisons of strain-dependent differences in host gene expression [12].
The host gene expression profile was markedly disturbed by the effects of the disease.
Viruses also disrupt host gene transcription by preventing transcriptional machinery assembly at gene promoters.
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