The most widely described endpoint is estrogenicity, but other hormonal disturbances, e.g., thyroid hormone disruption, are gaining more and more attention.
Reported additional modes of action [9] include liver damage [10], [11], [12], [13], [14], disrupted pancreatic Beta-cell function [15], thyroid hormone disruption [16] and obesity promoting effects [17].
Triclosan's potential for hormone disruption (the science is strongest in support of its potential to disrupt thyroid function) is particularly problematic for Avon, which is arguably more visibly tied to pink-ribbon marketing and breast-cancer awareness than any other cosmetics company.
Pesticides definitively contribute to cancer, developmental disabilities, and reproductive and hormone disruption.
These compounds have also been implicated in hormone disruption of animals in terrestrial, aquatic, and marine habitats.
Thyroid hormone disruption likely played an important role in the metamorphosis delay as the T3 T4 ratio was lowest in tadpoles raised in young, tailings-affected wetlands.
Among the first chemicals proposed for review are lead acetate, a suspected neurotoxin found in hair dyes, and propylparaben, a preservative in shampoos and lotions linked to hormone disruption.
The E.P.A. complied with the Data Quality Act and revised its Environmental Risk Assessment, making it clear that hormone disruption wouldn't be a legitimate reason for restricting use of the chemical until "appropriate testing protocols have been established".
From 2002 to 2013, the flame retardants most commonly used in electronics, polybrominated diphenyl ethers (PBDEs), were banned or phased out in Europe and the US after researchers linked the compounds to neurotoxic effects and hormone disruption.
The group cited various studies suggesting that exposure to 2,4-D could cause cancer, hormone disruption, genetic mutations and neurotoxicity.
Health implications from long-term exposure to toxic pesticide levels may include learning difficulties, hormone disruption and reproductive abnormalities, Greenpeace said.
