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The spectrum of recently horizontally acquired sequences identified emphasizes the two driving forces of horizontal exchange: the transfer of a phenotype which alters or enhances bacterial fitness resulting in increased competitive fitness or altered niche adaptation, and the presence of a substrate for homologous recombination.
Several low G+C regions indicated the presence of horizontally acquired sequences.
The chromosome of Salmonella enterica comprises largely of a core sequence punctuated with horizontally acquired sequences [ 29].
Horizontally acquired sequences are detectable by, among others, their dinucleotide composition (genome signature) dissimilarity with the host genome.
New implementations of signature analysis that can be applied on a gene-by-gene basis for the identification of horizontally acquired sequences are described.
The influence of FNR on this process is more extensive than previously appreciated, although aside from the virulence plasmid, this transcriptional regulator does not govern expression of genes on other horizontally acquired sequences on the chromosome such as pathogenicity islands.
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Furthermore, if a horizontally acquired sequence is inserted randomly into a genome, it may disrupt the existing gene at the point of insertion.
RNA sequences are frequently sights for integration of horizontally acquired DNA sequences, in some cases leading to duplication of the RNA [ 5- 7].
Furthermore, simultaneous inactivation of hha and ydgT in S. enterica induced numerous genes located in AT-rich, horizontacquireduireDNANA sequences, many of which are reported to be targets of H-NS.
In 1990, it was first observed that large blocks of horizontally acquired foreign sequences occur in chromosomes of pathogenic bacteria, and those regions are highly correlated with pathogenicity [ 1- 3].
Therefore, even if HGT between plant parasites and their hosts is very rare, through time this could result in plant genomes that are complex chimeras of horizontally as well as vertically acquired sequences.
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