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The present-day concept that osteoarthritis may be amenable to biological modification rather than a hopeless expression of old age or injury has historical roots in the period of 1935 through the early 1970s.
The hopeless expression on her face was gone and so was her limp.
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Confined to our closet-sized living accommodations, our expressions turn hopeless as we look out of the windows, peering at the cross street, terrified of what lies beneath your shiny surface.
The DSI is a scale that sums responses from the following five items: Sad or pained facial expressions, made negative statements, self-depreciation, expressions of guilt/shame, hopeless.
Thinking on own suicide can also be seen as an expression of a hopeless situation.
At times, the camera lingers too long on the expressions of a jilted Nancy or an overwhelmed Michael or a hopeless Hope, and those are the looks no one shows you in real life much anymore, much less on TV.
All hopeless.
It feels hopeless.
It seems hopeless".
The hopeless emptiness.
"Hopeless," Renshaw said.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com