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Some hope derives from recent findings such as the identification of leucine-rich-repeat and Ig-domain-containing 1 (LINGO-1), the wnt pathway and retinoic acid receptor gamma (RXR-γ) as potential therapeutic targets (Fancy et al, 2011; Huang et al, 2011; Mi et al, 2007).
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Like the Cursing Mommy, we're trying to ignore life's awfulness, live in hope, derive happiness from our work... and locate the goddamn edge on the goddamn roll of tape.
Hopes derived from rather short-term labelling trials and pathophysiological studies assessing CV biomarkers or CV surrogate outcomes may turn out to be erroneous when the longer term outcome results from RCTs become available.
President Bush, who promised Medicare drug benefits in the 2000 campaign, hailed the deal, from which Republicans hope to derive huge political dividends.
"They have come for the gratification that they hope to derive from these dances," Wilson writes, "but this vision of erotic ecstasy, when they see it unveiled before them though they watch it with fascination frightens them".
I am hoping my book reaches a global audience, both within the CF community, which I hope will derive some hope and survival strategies from my story, and with a wider audience who will hopefully understand CF better and appreciate what it takes to combat it on a daily basis.
But whether the orchestra succeeds in enriching the experience of San Francisco's rather conservative classical music audiences will depend on how much it can realistically hope to derive from the artists' intensive yet still truncated sojourns.
"They have come for the gratification that they hope to derive from these dances," Wilson writes, "but this vision of erotic ecstasy, when they see it unveiled before them — though they watch it with fascination — frightens them".
The stronger one's epistemological premise, the better the hope of deriving a metaphysical conclusion.
However, even with this variable transformation, there seems to be little hope to derive a precise Kramers' rule for the stochastic Amari model (2) by generalizing the approach for SPDE systems [4, 6, 7].
We hope the derived results in this study could facilitate better understanding on the fault zone dynamics, especially for viscous ductile deformation feature, which is often observed within and nearby fault zones in the field.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com