Individual eIF4G isoforms also appear to be at work in Drosophila and mouse spermatocytes, where eIF4G homologue, off-schedule (eIF4G2), and Repro8 (eIF4G3), respectively, have been identified as integral regulators of meiotic progression and differentiation [ 61, 75, 76].
This genetic network was able to program intricate expression dynamics of the key transcription factors Ngn3 (neurogenin 3, OFF-ON-OFF), Pdx1 (pancreatic and duodenal homeobox 1, ON-OFF-ON) and MafA (V-maf musculoaponeurotic fibrosarcoma oncogene homologue A, OFF-ON) to guide the differentiation of IPSC-derived pancreatic progenitor cells to beta-like cells.
And for decades the clitoris has been described in medical textbooks as "a poor homologue of the male".
The homologue of UL11 in MHV-68 is ORF38.
eIF4E2 is a homologue of eIF4E (Rom et al., 1998).
This element, the second-heaviest ever created, is a homologue of astatine, meaning that it sits right below astatine on the periodic table and likely shares similar properties.
No clear homologue of Rbd2 was detected.
Ace1 is a homologue of Amt1.
The exception to this is the five endophytic species analysed which frequently returned no significant sequence homologues (highest e value cut off used = e−10).
All sequences were submitted for blastn and blastx searches against nr database; an e-value < 10-5 was used as cut-off for confidential homologue detection.
Humans lack this combination of molecules, but researchers will, by this point, have produced a human homologue to the newt's special juice.
