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However, a homologous origin of the same basic domain architecture in some ancestral MetaHox gene is suggested by the common domain order within the Msx, NK and Tlx coding sequences, the close phylogenetic relationship of all their homeodomain sequences, and the evidence for ancient clustering of these genes into MetaHox homeobox gene clusters.
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However, most progeny did not display complex recombination products at this locus that would confirm a meiotic homologous recombination origin.
Author's response: Despite a rigorous search I could not identify homologous parental origin for any novel intron elsewhere within the placental and marsupial genomes, consistent with the other studies about the intron gain.
Family I (Bilirubin Oxidases) contains proteins of which 70% were of bacterial origin (homologous families I1 I5), 15% of plant origin (homologous family I3), 10% of fungal origin (homologous family I1) and 5% of unspecified source organism.
Family J (Bacterial CueO Proteins) contains proteins of which 90% were of bacterial origin (homologous families J1 J4) and 10% of eukaryotic origin (homologous family J5).
The arrangement of bones is so different from that of modern fishes with bony skeletons that it is unlikely that the bones of the two groups are homologous (similar in origin).
Lying ventral to the intervertebral disks in some mammals (e.g., whale, pangolin) are paired ossicles, the intercentra, which are homologous (of similar origin) with the anterior arch of the atlas.
Family C (Insect Laccases) resulted in 78% proteins of insect origin (homologous families C1 C8).
Family F (Fungal and Plant Ascorbate Oxidases) mainly contain proteins of plant origin (homologous families F2 F6).
The other proteins are all of bacterial origin (homologous families B2 B6) and 3% are annotated as laccases in GenBank.
Family H (Bacterial CopA Proteins) contains proteins of which 98% were of bacterial origin (homologous families H1 H6).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com